Table 3.

Plasma Basal Concentrations and Stimulated Corticotropin and Cortisol Response to oCRH (0.4 μg/kg) and Naloxone (125 μg/kg) in 1-Month-Abstinent Male Alcohol-Dependent Participants and Age-Matched Healthy Controls

	oCRH Stimulation Test				Naloxone Stimulation Test
	Alcohol Dependent	Controls	t (19)	p	Alcohol Dependent	Controls	t (18)	p
Basal corticotropin (pg/ml) (1930–2000 hr)	23.0 ± 8.9	18.9 ± 4.5	1.31	NS	21.4 ± 7.8	17.8 ± 4.6	1.26	NS
Basal cortisol (μg/dl) (1930–2000 hr)	3.9 ± 2.4	3.6 ± 1.2	0.42	NS	2.4 ± 1.5	3.1 ± 0.7	1.27	NS
Cortisol binding globulin (μg/ml)	33.0 ± 7.2	36.3 ± 6.3	1.10	NS	32.6 ± 7.5	36.3 ± 6.3	1.16	NS
Free cortisol index	0.17 ± 0.09	0.14 ± 0.03	1.03	NS	0.11 ± 0.06	0.12 ± 0.03	0.80	NS
Net integrated corticotropin response (pg/ml.2 hr)	2518 ± 1242	2051 ± 801	1.01	NS	878 ± 528	538 ± 392	1.64	NS
Net integrated cortisol response (μg/dl.2 hr)	715 ± 261	1027 ± 235	2.86	0.01	346 ± 305	326 ± 271	0.15	NS