Table 2.
Number of FISH Signals per Cell for Each DNA Target Tested and Frequencies of Abnormal Cells per Target of Cells with a Hyper-Aneusomic Pattern and a Clustered Amplification Pattern in the 20 NSCLC Specimens
| NSCLC | Stage | 5p15 | CEP 6 | 7p12 | 8q24 | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Ab | % HA | Range | Modal | Average | SD | % Ab | Range | Modal | Average | SD | % Ab | % HA | % Amp | Range | Modal | Average | SD | % Ab | % HA | % Amp | Range | Modal | Average | SD | ||
| BAC1 | IA | 70 | 1–4 | 4 | 3.3 | 1.07 | 71 | 1–5 | 4 | 3.4 | 1.17 | 77 | 32 | 2–8 | 4 | 4.1 | 1.38 | 76 | 2–8 | 3 | 3.5 | 1.12 | ||||
| BAC2 | IIA | 95 | 2–5 | 4 | 3.9 | 0.52 | 95 | 2–5 | 4 | 3.9 | 0.69 | 97 | 2–6 | 3 | 3.6 | 0.74 | 95 | 2–6 | 4 | 4.0 | 0.79 | |||||
| BAC3 | IV | 100 | 3–13 | 5 | 5.8 | 2.45 | 99 | 2–12 | 2 | 4.8 | 2.33 | 100 | 40 | 3–15 | 4 | 7.6 | 3.61 | 99 | 40 | 2–21 | 5 | 8.8 | 4.43 | |||
| BAC4 | II | 96 | 15 | 2–13 | 5 | 7.3 | 2.40 | 92 | 2–12 | 5 | 5.5 | 1.91 | 99 | 15 | 2–10 | 4 | 7.3 | 2.14 | 96 | 2–10 | 5 | 5.2 | 1.63 | |||
| BAC5 | IB | 5 | 1–3 | 2 | 2.0 | 0.24 | 5 | 1–3 | 2 | 2.0 | 0.27 | 10 | 2–4 | 2 | 2.1 | 0.37 | 7 | 2–4 | 2 | 2.1 | 0.35 | |||||
| BAC6 | IB | 97 | 2–10 | 5 | 5.5 | 1.37 | 48 | 1–5 | 2 | 2.5 | 0.80 | 96 | 2–10 | 4 | 4.5 | 1.31 | 96 | 2–7 | 4 | 4.2 | 1.01 | |||||
| BAC7 | IB | 24 | 2–4 | 2 | 2.2 | 0.57 | 11 | 1–4 | 2 | 2.1 | 0.48 | 23 | 2–5 | 2 | 2.5 | 0.81 | 20 | 1–5 | 2 | 2.3 | 0.72 | |||||
| ADC1 | IA | 10 | 1–4 | 2 | 2.0 | 0.44 | 8 | 1–4 | 2 | 2.1 | 0.47 | 94 | 2–8 | 4 | 4.0 | 1.31 | 21 | 2–6 | 2 | 2.4 | 0.85 | |||||
| ADC2 | IIIA | 60 | 2–10 | 2 | 3.6 | 1.80 | 84 | 2–5 | 2 | 3.0 | 1.35 | 100 | 3–6 | 3 | 4.6 | 1.92 | 90 | 2–9 | 3 | 3.7 | 1.47 | |||||
| ADC3 | IIB | 100 | 3–10 | 8 | 7.3 | 1.54 | 100 | 6–8 | 6 | 5.4 | 1.21 | 100 | 3–10 | 8 | 7.9 | 1.33 | 100 | 3–8 | 6 | 5.8 | 0.80 | |||||
| SCC1 | IIB | 61 | 1–8 | 2 | 3.3 | 2.02 | 61 | 1–5 | 2 | 2.7 | 1.03 | 75 | 2–7 | 3 | 3.2 | 1.09 | 57 | 2–10 | 2 | 3.8 | 2.32 | |||||
| SCC2 | I | 97 | 2–7 | 4 | 3.8 | 0.83 | 97 | 2–5 | 3 | 3.1 | 0.47 | 100 | 3–9 | 4 | 4.6 | 1.13 | 97 | 2–9 | 4 | 4.2 | 1.03 | |||||
| SCC3 | IIA | 44 | 1–6 | 2 | 2.8 | 1.01 | 30 | 1–5 | 2 | 2.3 | 0.59 | 64 | 2–5 | 3 | 2.7 | 0.74 | 50 | 14* | 6 | 2–5 | 2 | 2.7 | 0.77 | |||
| SCC4 | II | 61 | 2–7 | 3 | 3.0 | 1.05 | 63 | 1–7 | 3 | 3.0 | 1.15 | 77 | 56 | 3–12 | 4 | 3.6 | 1.63 | 73 | 2–7 | 3 | 3.2 | 1.18 | ||||
| SCC5 | IV | 100 | 60 | 6–15 | 12 | 10.5 | 2.91 | 100 | 3–9 | 5 | 4.6 | 0.98 | 100 | 3–7 | 4 | 4.5 | 1.50 | 100 | 10 | 3–11 | 6 | 6.3 | 1.44 | |||
| SCC6 | II | 64 | 2–7 | 2 | 3.4 | 1.39 | 62 | 2–5 | 2 | 3.0 | 1.01 | 90 | 2–6 | 3 | 3.5 | 1.03 | 68 | 2–6 | 3 | 3.0 | 0.89 | |||||
| SCC7 | IB | 48 | 2–6 | 2 | 2.6 | 0.87 | 26 | 1–4 | 2 | 2.3 | 0.64 | 76 | 2–5 | 3 | 2.9 | 0.73 | 66 | 1–6 | 3 | 3.0 | 0.98 | |||||
| SCC8 | IIB | 96 | 26 | 2–16 | 6 | 7.4 | 3.06 | 98 | 2–9 | 3 | 4.6 | 1.58 | 100 | 16 | 3–12 | 6 | 5.9 | 2.34 | 100 | 3–11 | 4 | 5.6 | 2.19 | |||
| SCC9 | IB | 100 | 3–8 | 5 | 4.8 | 1.15 | 91 | 2–8 | 3 | 3.6 | 1.15 | 100 | 3–10 | 4 | 5.4 | 1.51 | 100 | 12* | 4–15 | 5 | 5.7 | 2.24 | ||||
| SCC10 | IB | 19 | 2–6 | 2 | 2.4 | 1.07 | 19 | 2–6 | 2 | 2.3 | 0.76 | 37 | 2–7 | 2 | 2.6 | 1.05 | 21 | 2–4 | 2 | 2.4 | 1.05 | |||||
Split signals may indicate double minutes.
Numbers of FISH signals per cell are range, mode, average and SD.
% Ab, Frequency of abnormal cells per target.
% HA, Frequency of hyper-aneusomic pattern.
% Amp, Frequency of clustered amplification pattern.