Table 3.

Patient Demographics, Pathological, and FISH Results in Bronchial Epithelium of Smoker Patients

Patient	Sex	Smoking status	Pack-years	Lung tumor	Site	Histology at culture site	Average histology score	Highest histology score	Dysplasia index	5p15 (12%)	Cen 6 (8%)	7p12 (12%)	8q24 (9%)
1	M	1	30	No	RB3	1	2.4	6	0.31	0	0	1.1	0
2	F	1	30	No	RUL	2	2.1	5	0.2	12.8	10.6	21.3	12.8
3	F	2	30	No	RB6	5.5	2.6	5	0.29	8.4	4.7	3.7	8.4
RML	1	2.6	5	0.29	7.1	0	4.8	4.8
4	F	2	34	No	RML	1	1	1	0	0.5	0	3.2	1.1
5	F	2	34.5	No	RUL	2	2.7	5	0.33	6	6	7.2	7.2
6	M	1	35	No	LUDB	1	1.75	6	0.13	2.4	3.6	6	3.6
7	M	2	40	No	RB6	5.5	3.7	5	0.43	0.6	0	0.6	0
8	F	1	40	No	LUL	1	1.3	2	0	0	1.1	2.1	1.1
RML	2	1.3	2	0	1	1.9	1.9	1
9	F	1	40	No	LB6	5.5	4.7	6	0.83	4	2.6	5.3	4
RUL	5.5	4.7	6	0.83	12.2	4.1	8.2	12.2
10	M	1	41	No	LB6	4	2.3	5	0.38	0	1	1	2
LUDB	1	2.3	5	0.38	1.1	4.5	2.3	3.4
11	M	2	45	No	RB6	2	3.4	5	0.67	8.5	5.3	7.5	7.5
12	M	2	47	No	RUL	4	2.3	6	0.29	0	0	0	0
13	F	2	47	No	LUDB	5.6	4.6	6	0.78	0	1.1	0	1.1
RML	5.6	4.6	6	0.78	1.7	5.2	6.9	6.9
14	M	2	52.5	No	LUL	4	3.45	5	0.72	10.2	10.2	15.3	11.9
RML	5.5	3.45	5	0.72	31.7	31.7	31.7	31.7
15	F	2	60	No	RML	4	1.6	4	0.13	0	0	0	0
16	M	1	60	No	LB4	1	2	5	0.33	1	1	1	2
LUDB	1	2	5	0.33	4.6	2.3	5.8	5.8
17	M	2	64	No	RB6	1	1.7	4	0.2	21.2	21.2	21.2	21.2
18	F	1	67.5	No	MC	5.5	1.71	5	0.14	2.6	2.6	1.3	1.3
19	F	1	67.5	No	RB6	N/A	1.1	2	0	12	11.4	12	12.7
20	M	1	70	No	MC	1	1.6	5	0.14	1.9	1.3	2.5	1.9
21	M	1	70	No	RUL	1	1.4	2	0	2.1	3.2	1.1	2.1
22	M	2	70	No	LUDB	4.1	3.9	5	0.85	2.1	1	0	1
RML	2	3.9	5	0.85	2	3.1	2	2
23	M	2	75	No	LUL	N/A	2	4	0.25	0	0	0.6	0
24	M	2	75	No	LUL	1	2	5	0.29	11.5	11.5	12	11.5
25	M	2	75	No	LB1	2	3.8	5	0.7	2.1	4.3	6.4	2.1
LUDB	5.5	3.8	5	0.7	2.2	0	3.2	1.1
26	M	1	80	No	LUDB	5.5	3.3	5	0.57	0.9	1.8	0.9	1.8
M	1	80	No	RML	4	3.3	5	0.57	5.9	4	5.9	4
27	M	2	90	No	LBL	1	2.4	5	0.33	16.5	13.2	13.2	13.2
LUL	1	2.4	5	0.33	3.8	3.8	9.4	5.7
28	M	1	100	No	LUL	7	7	7	1	1	0	0.5	0.5
29	M	2	100	No	MC	1	3.4	5	0.56	16.7	16.7	17.8	18.9
30	M	1	135	No	RB2	1	1.6	4	0.13	1.2	0.6	0.6	0.6
LUL	1	1.6	4	0.13	0	0	0	6.1
31	M	1	357.5	No	LUDB	1	1	1	0	0	1.5	2.9	0
32	M	2	65	No	LUL	2	3.5	6	0.2	2.2	3.2	0	3.2
33	M	2	47	No	LUL	5.6	3.5	6	0.5	0	1.1	2.2	0
34	F	2	30	Adenoca	LLL	5.6	8	8.8	11.4	4.4	9
35	F	2	38	Adenoca	RUL/RML	2	8	0	0	1.1	0.5
36	M	2	39	SqCa	RML/RLL	2	8	0.6	0.6	1.9	0.6
37	M	2	45	SqCa	LB6	1	8	8.5	7.6	10.4	9.4
38	M	1	90	SqCa	LLL	2	8	5	1	3	2
39	F	2	105	Carcinoid	RUL	2	8	3.3	1.1	7.6	3.3
40	F	2	135	Adenoca	RUL	2	8	11.1	11.1	9.1	10.1
41	M	1	70	SqCa	RB6	1	8	0	0	1.8	0
42	M	1	51	SqCa	LUL	2	8	0	0	0	0

Frequency of cells with abnormal number of copies per probe are identified per specimen.

Cut-off frequencies were defined adjusting for 100% specificity.

Boldfacevalues represent percentages above the threshold.