Table 3A.
Mean (± SEM) FP Values for R110 Incorporation for Each Genotype
| Loci | Genotype* | P-value† | ||
|---|---|---|---|---|
| W/W | W/w | w/w | ||
| TNF-α (−308) | 70.7 (± 0.7) | 57.0 (± 1.7) | 1.3 (± 0.8) | P < 0.0001 |
| TNF-α (−238)‡ | 87.9 (± 0.6) | 79.1 (± 2.0) | N/A | P < 0.0001 |
| TNF-β (± 250) | 15.5 (± 1.4) | 105.8 (± 1.3) | 117.0 (± 2.6) | P < 0.0001 |
| IL-1 (+3953) | 142.3 (± 0.7) | 122.9 (± 1.7) | 5.5 (± 1.6) | P < 0.0001 |
| IL-6 (−174) | 100.0 (± 1.7) | 58.0 (± 1.4) | 7.3 (± 1.4) | P < 0.0001 |
| IL-10 (−592) | 80.9 (± 0.8) | 52.3 (± 1.4) | 1.5 (± 4.2) | P < 0.0001 |
| PAI-1 (−675) | 15.5 (± 2.1) | 109.8 (± 0.7) | 120.6 (± 1.5) | P < 0.0001 |
| TLR4299 | 13.2 (± 0.8) | 111.0 (± 5.3) | N/A | P < 0.0001 |
W denotes the more frequent genotype, w denotes the variant genotype (SNP).
P-value (ANOVA) comparing genotypes.
While these results are statistically different, W/W and W/w genotypes are more readily distinguished on the basis of differences in TAMARA incoporation.