Table 3.
Multivariable rate ratio (MV RR) and 95% confidence interval (CI) of glioma by pack-years of smoking before or after age 30 years among men in the Health Professionals Follow-up Study (HPFS, 1986–2002) and women in the Nurses’ Health Study (NHS, 1976–2002) and the NHS II (1989–2003)
|
Pack-years of Smoking beforeAge 30 Years |
|||||
|---|---|---|---|---|---|
| 0 | 1–4 | 5–10 | >10 | Trend Testpvalue | |
| Cases/person-yearsa | 194/2,867,124 | 70/820,124 | 58/750,292 | 43/618,605 | |
| MV RR (95% CI)b,c,d | 1.00 (reference) | 1.17 (0.88–1.56) | 1.14 (0.82–1.58) | 1.04 (0.71–1.53) | 0.81 |
|
Pack-years of Smoking after Age 30 Years |
|||||
|---|---|---|---|---|---|
| 0 | 1–9 | 10–20 | >20 | Trend Testpvalue | |
| Cases/person-yearsa | 208/3,280,859 | 53/775,774 | 52/496,375 | 52/503,172 | |
| MV RR (95% CI)b,c,e | 1.00 (reference) | 1.40 (0.99–1.94) | 1.31 (0.92–1.87) | 1.15 (0.80–1.65 | 0.94 |
Person-years do not add up to total due to missing information on number of cigarettes smoked (converted into pack-years) in each age category.
Pooled RR and trend test p value obtained from pooling the beta-coefficient and standard error estimates for men and women by using the DerSimonian and Laird38 random-effects model (no evidence of heterogeneity by sex; pvalues for heterogeneity for each category were >0.9).
Adjusted for age, total meat intake, and alcohol and coffee consumption.
Additionally adjusted for continuous pack-years of smoking after age 30.
Additionally adjusted for continuous pack-years of smoking before age 30.