Table 1.
Clinical parameters and associations between presence and absence of thrombocytosis in all patients with glioblastoma (n = 153)
| Parameter | < 400 Platelets/nl (n = 124) | > 400 Platelets/nl (n = 29) | Test | PValue |
|---|---|---|---|---|
| Age (years) | 64.9 ± 11.1 (n =124) | 64.8 ± 10.4 (n =29) | t-test | 0.9498 |
| KPS | 80 (40–100; n =124) | 80 (20–90; n =26) | Mann-Whitney test | 0.7636 |
| Tumor volume (ml) | 24.8 ± 21.8 (n =55) | 38.9 ± 22.5 (n =12) | t-test | 0.0481 |
| Platelet count (per nl) | 276 ± 62 (n = 124) | 451 ± 54 (n = 29) | t-test | < 0.0001 |
| Hemoglobin (g/100 ml) | 14.5 ± 1.4 (n =124) | 14.3 ± 1.6 (n =29) | t-test | 0.3978 |
| aPTT (s) | 23.6 ± 3.2 (n =117) | 24.4 ± 3.4 (n =28) | t-test | 0.2471 |
| Prothrombin time (%) | 98.8 ± 13.8 (n =122) | 99.0 ± 10.3 (n =29) | t-test | 0.9377 |
| Fibrinogen (g/l) | 2.9 ± 1.0 (n = 79) | 3.7 ± 1.7 (n = 23) | t-test | 0.0323 |
| Smokers | 16 (14.3%) | 5 (18.5%) | Fisher’s exact test | 0.5588 |
| Nonsmokers | 96 (85.7%) | 22 (81.5%) | ||
| Female | 49 (39.5%) | 14 (48.3%) | Chi-square test | 0.3882 |
| Male | 75 (60.5%) | 15 (51.7%) | ||
| Biopsy only | 29 (23.4%) | 11 (38.0%) | Chi-square test | 0.0392 |
| Incomplete resection | 24 (19.4%) | 9 (31.0%) | ||
| Complete resection | 71 (57.3%) | 9 (31.0%) | ||
| No RT or CT | 17 (13.7%) | 9 (31.0%) | Chi-square test | 0.079 |
| RT only | 55 (44.4%) | 11 (38.0%) | ||
| RT and CT | 52 (41.9%) | 9 (31.0%) |
Abbreviations: aPTT, activated partial thromboplastin time; RT, radiation therapy, CT, chemotherapy. Note that for these analyses, all patients with glioblastoma, regardless of their further therapy or other parameters, were included. All quantitative parameters are given as mean ± 1 SD; KPS is given as median and range; the qualitative parameters are expressed in frequencies or number of patients (%). The degree of tumor resection was based on the surgeon’s report.