Table 3.
Clinical parameters and associations between presence and absence of thrombocytosis in all operated patients with subsequent radiation therapy with or without additional chemotherapy
| Parameter | < 400 Platelets/nl (n = 87) | > 400 Platelets/nl (n = 11) | Test | PValue |
|---|---|---|---|---|
| Age (years) | 63.3 ± 11.1 (n =87) | 65.8 ± 6.4 (n = 11) | t-test | 0.4620 |
| KPSa | 80 (50–100; n =86) | 80 (50–90; n =11) | Mann-Whitney test | 0.6618 |
| Tumor volume (ml) | 23.5 ± 20.3 (n =37) | 48.7 ± 23.1 (n =4) | t-test | 0.0248 |
| Platelet count (per nl) | 275 ± 65 (n =87) | 440 ± 42 (n =11) | t-test | < 0.0001 |
| Hemoglobin (g/100 ml) | 14.5 ± 1.4 (n = 87) | 14.2 ± 1.7 (n = 11) | t-test | 0.6376 |
| aPTT (s) | 23.2 ± 2.9 (n = 81) | 24.4 ± 2.7 (n = 10) | t-test | 0.2069 |
| Prothrombin time (%) | 99.8 ± 11.0 (n =86) | 97.5 ± 13.4 (n =11) | t-test | 0.5382 |
| Fibrinogen (g/l) | 2.7 ± 1.0 (n = 51) | 3.2 ± 1.5 (n = 7) | t-test | 0.4248 |
| Smokers | 12 (15%) | 3 (30%) | Fisher’s exact test | 0.3610 |
| Nonsmokers | 68 (85%) | 7 (70%) | ||
| Female | 36 (41.4%) | 5 (45.5%) | Fisher’s exact test | 1.0000 |
| Male | 51 (58.6%) | 6 (54.5%) | ||
| Incomplete resection | 20 (23.0%) | 3 (27.3%) | Fisher’s exact test | 0.7164 |
| Complete resection | 67 (77.0%) | 8 (72.7%) | ||
| RT only | 43 (49.4%) | 4 (36.4%) | Chi-square test | 0.4139 |
| RT and CT | 44 (50.6%) | 7 (63.6%) |
Abbreviations: aPTT, activated partial thromboplastin time; RT, radiation therapy, CT, chemotherapy. Nonoperated patients or operated patients without subsequent RT were excluded from this analysis. All quantitative parameters are given as mean ± 1 SD or number of patients (%); KPS is given as median and range; the qualitative parameters are expressed in frequencies.