Table 2.
Activity of VNP40101M at three dose levels for five days in the treatment of D-245 MG xenografts
| VNP40101M Dose (mg/kg) | T-Ca | Tumor Regressionsb* | Toxic Deaths |
|---|---|---|---|
| 13.5 | < 60 | 8 of 9 | 1 |
| 9.0 | 53.5* | 9 of 10 | 0 |
| 18.0 | < 60 | 9 of 10 | 0 |
a
The response of subcutaneous xenografts was assessed by delay in growth of tumor in mice treated with drug as compared with growth in control mice (T-C). The growth delay is the difference (measured in days) between the median time required for tumors in treated (T) and control (C) mice to reach five times the size at the initiation of therapy and greater than 1,000 mm 3 or whichever was higher.
b
Tumor regression was defined as a decrease in tumor volume over two successive measurements.
*
p < 0.001 compared with control.