Table 3.
Activity of VNP40101M (10 mg/kg) and of VNP40101M plus O6-benzylguanine (BG) in D-456 MG and D-341 MED xenografts
| Xenograft | AGT (fmol/mg Protein) | Treatment | T-Ca | Regressionsb | Toxic Deaths |
|---|---|---|---|---|---|
| D-456 MG | 94.0 ± 16.6 | VNP40101M | 2.0 | 0 of 10 | 0 |
| VNP40101M + BG | 4.6 | 0 of 10 | 0 | ||
| D-341 MED | 385.5 6 206.5 | VNP40101M | 3.6 | 0 of 10 | 0 |
| VNP40101M + BG | 14.5* | 4 of 10 | 0 |
Abbreviation: AGT, O6-alkylguanine-DNA alkyltransferase.
a
The growth delay (T-C) is the difference (measured in days) between the median time for tumors in treated (T) and control (C) mice to reach five times the volume recorded at the beginning of treatment.
b
Tumor regression was defined as a decrease in tumor volume over two successive measurements.
*
p < 0.001.