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British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1992 Apr;105(4):768–770. doi: 10.1111/j.1476-5381.1992.tb09053.x

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter.

R G Bogle 1, S Moncada 1, J D Pearson 1, G E Mann 1
PMCID: PMC1908727  PMID: 1380372

Abstract

The effects of inhibitors of nitric oxide (NO) synthase and other cationic amino acids on unidirectional L-arginine transport were studied in porcine aortic endothelial cells cultured in microwell plates or perfused in microcarrier columns. L-Homoarginine, L-lysine and L-ornithine inhibited transport of L-arginine. The NO synthase inhibitors NG-monomethyl-L-arginine and NG-iminoethyl-L-ornithine also reduced L-arginine uptake, whereas NG-nitro-L-arginine and its methyl-ester had no inhibitory effect. The ability to modulate selectively endothelial cell L-arginine transport or NO synthase activity will allow further characterization of the arginine transporter and its role in regulating NO biosynthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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