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. 1996 Jun;118(4):984–988. doi: 10.1111/j.1476-5381.1996.tb15496.x

Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes.

S C Tsai 1, Y C Chiao 1, C C Lu 1, M L Doong 1, Y H Chen 1, H C Shih 1, C Liaw 1, S W Wang 1, P S Wang 1
PMCID: PMC1909523  PMID: 8799572

Abstract

1. The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3':5'-cyclic monophosphate (cyclic AMP) in rats was studied. 2. A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine. 3. Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone. 4. Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes. 5. These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production.

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Selected References

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