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. 1994 Apr;111(4):1029–1034. doi: 10.1111/j.1476-5381.1994.tb14847.x

Induction of kinin B1 receptor-dependent vasoconstriction following balloon catheter injury to the rabbit carotid artery.

D Pruneau 1, J M Luccarini 1, C Robert 1, P Bélichard 1
PMCID: PMC1910121  PMID: 8032586

Abstract

1. Balloon catheter injury to the rabbit carotid artery damaged the endothelium and induced neointima formation over 7 days. The area of intima, expressed as a percentage of the media, was 16.2 +/- 4.2% and 8.2 +/- 0.1% in balloon catheter-injured and sham-operated arteries. 2. Seven days after arterial injury, carotid arteries were isolated and set up as ring preparations in organ baths for isometric tension measurements. Balloon catheter-injured arteries first contracted with noradrenaline (0.01-0.1 microM), contracted further in a concentration-dependent manner to bradykinin (BK; pD2, 5.98 +/- 0.22; Emax, 41.3 +/- 5.2% of KCl) and to des-Arg9-BK (pD2, 7.12 +/- 0.36; Emax, 46.0 +/- 9.9% of KCl). In contrast, vessel segments with endothelium either intact or acutely removed were unresponsive to both BK receptor agonists. 3. The concentration-contraction curves for BK and for des-Arg9-BK were shifted to the right by the B1 receptor antagonist, [Leu8]des-Arg9-BK (3 microM), but not by the selective B2 receptor antagonist, Hoe 140 (1 microM). 4. Thus, BK and its metabolite, des-Arg9-BK act as vasoconstrictor agents following balloon catheter injury. These effects appear to be mediated by activation of B1 receptors.

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Selected References

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  1. Azuma H., Niimi Y., Hamasaki H. Prevention of intimal thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan. Br J Pharmacol. 1992 Jul;106(3):665–671. doi: 10.1111/j.1476-5381.1992.tb14392.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berk B. C., Gordon J. B., Alexander R. W. Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty. J Am Coll Cardiol. 1991 May;17(6 Suppl B):111B–117B. doi: 10.1016/0735-1097(91)90946-7. [DOI] [PubMed] [Google Scholar]
  3. Bhoola K. D., Figueroa C. D., Worthy K. Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol Rev. 1992 Mar;44(1):1–80. [PubMed] [Google Scholar]
  4. Briner V. A., Tsai P., Schrier R. W. Bradykinin: potential for vascular constriction in the presence of endothelial injury. Am J Physiol. 1993 Feb;264(2 Pt 2):F322–F327. doi: 10.1152/ajprenal.1993.264.2.F322. [DOI] [PubMed] [Google Scholar]
  5. Bönner G., Schunk U. Hypotensive effect of bradykinin in normotensives and patients with renovascular hypertension. Adv Exp Med Biol. 1986;198(Pt B):321–327. doi: 10.1007/978-1-4757-0154-8_40. [DOI] [PubMed] [Google Scholar]
  6. Campbell D. J., Kladis A., Duncan A. M. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155–165. doi: 10.1161/01.hyp.21.2.155. [DOI] [PubMed] [Google Scholar]
  7. Cocks T. M., Kemp B. K., Pruneau D., Angus J. A. Comparison of contractile responses to 5-hydroxytryptamine and sumatriptan in human isolated coronary artery: synergy with the thromboxane A2-receptor agonist, U46619. Br J Pharmacol. 1993 Sep;110(1):360–368. doi: 10.1111/j.1476-5381.1993.tb13818.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Deblois D., Marceau F. The ability of des-Arg9-bradykinin to relax rabbit isolated mesenteric arteries is acquired during in vitro incubation. Eur J Pharmacol. 1987 Oct 6;142(1):141–144. doi: 10.1016/0014-2999(87)90664-9. [DOI] [PubMed] [Google Scholar]
  9. Gabaldón M. Methodological approaches for the study of the aortic endothelium of the rat. Atherosclerosis. 1987 May;65(1-2):139–149. doi: 10.1016/0021-9150(87)90015-3. [DOI] [PubMed] [Google Scholar]
  10. Goldstein R. H., Wall M. Activation of protein formation and cell division by bradykinin and des-Arg9-bradykinin. J Biol Chem. 1984 Jul 25;259(14):9263–9268. [PubMed] [Google Scholar]
  11. Kohler T. R., Jawien A. Flow affects development of intimal hyperplasia after arterial injury in rats. Arterioscler Thromb. 1992 Aug;12(8):963–971. doi: 10.1161/01.atv.12.8.963. [DOI] [PubMed] [Google Scholar]
  12. Liu M. W., Roubin G. S., King S. B., 3rd Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation. 1989 Jun;79(6):1374–1387. doi: 10.1161/01.cir.79.6.1374. [DOI] [PubMed] [Google Scholar]
  13. Marceau F., Lussier A., Regoli D., Giroud J. P. Pharmacology of kinins: their relevance to tissue injury and inflammation. Gen Pharmacol. 1983;14(2):209–229. doi: 10.1016/0306-3623(83)90001-0. [DOI] [PubMed] [Google Scholar]
  14. Nwator I. A., Whalley E. T. Angiotensin converting enzyme inhibitors and expression of des-Arg9-BK (kinin B1) receptors in vivo. Eur J Pharmacol. 1989 Jan 24;160(1):125–132. doi: 10.1016/0014-2999(89)90661-4. [DOI] [PubMed] [Google Scholar]
  15. Pelc L. R., Gross G. J., Warltier D. C. Mechanism of coronary vasodilation produced by bradykinin. Circulation. 1991 Jun;83(6):2048–2056. doi: 10.1161/01.cir.83.6.2048. [DOI] [PubMed] [Google Scholar]
  16. Pruneau D., Bélichard P. Induction of bradykinin B1 receptor-mediated relaxation in the isolated rabbit carotid artery. Eur J Pharmacol. 1993 Aug 3;239(1-3):63–67. doi: 10.1016/0014-2999(93)90976-o. [DOI] [PubMed] [Google Scholar]
  17. Regoli D. C., Marceau F., Lavigne J. Induction of beta 1-receptors for kinins in the rabbit by a bacterial lipopolysaccharide. Eur J Pharmacol. 1981 Apr 24;71(1):105–115. doi: 10.1016/0014-2999(81)90391-5. [DOI] [PubMed] [Google Scholar]
  18. Regoli D., Barabé J. Pharmacology of bradykinin and related kinins. Pharmacol Rev. 1980 Mar;32(1):1–46. [PubMed] [Google Scholar]
  19. Regoli D., Rhaleb N. E., Drapeau G., Dion S. Kinin receptor subtypes. J Cardiovasc Pharmacol. 1990;15 (Suppl 6):S30–S38. [PubMed] [Google Scholar]
  20. Ridray S., Capron L., Heudes D., Picon L., Ktorza A. Effects of fasting and refeeding on the proliferative response of rat aorta to injury. Am J Physiol. 1991 Jul;261(1 Pt 2):H190–H195. doi: 10.1152/ajpheart.1991.261.1.H190. [DOI] [PubMed] [Google Scholar]
  21. Roberts R. A., Gullick W. J. Bradykinin receptor number and sensitivity to ligand stimulation of mitogenesis is increased by expression of a mutant ras oncogene. J Cell Sci. 1989 Nov;94(Pt 3):527–535. doi: 10.1242/jcs.94.3.527. [DOI] [PubMed] [Google Scholar]
  22. Schwartz R. S., Holmes D. R., Jr, Topol E. J. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol. 1992 Nov 1;20(5):1284–1293. doi: 10.1016/0735-1097(92)90389-5. [DOI] [PubMed] [Google Scholar]
  23. Skidgel R. A. Bradykinin-degrading enzymes: structure, function, distribution, and potential roles in cardiovascular pharmacology. J Cardiovasc Pharmacol. 1992;20 (Suppl 9):S4–S9. doi: 10.1097/00005344-199200209-00003. [DOI] [PubMed] [Google Scholar]

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