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. 1997 Jan;71(1):729–733. doi: 10.1128/jvi.71.1.729-733.1997

Theiler's murine encephalomyelitis virus subgroup strain-specific infection in a murine macrophage-like cell line.

M Obuchi 1, Y Ohara 1, T Takegami 1, T Murayama 1, H Takada 1, H Iizuka 1
PMCID: PMC191107  PMID: 8985406

Abstract

We compared infection of a murine macrophage-like cell line, J774-1, with two Theiler's murine encephalomyelitis virus subgroup strains. The GDVII strain, which is highly virulent and produces acute polioencephalomyelitis in mice, did not actively replicate in J774-1 cells, although there was a significant inhibition in cellular protein synthesis. In contrast, the DA strain, which is less virulent and causes demyelination with a persistent virus infection, productively infected J774-1 cells; however, there was less virus produced than in BHK-21 cells, and there was little if any cellular protein shutoff. These in vitro data may provide some explanation for the biological activities that are observed between both subgroup strains.

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Selected References

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