Abstract
Growth rate and histology of splenic autotransplants in subcutaneous pockets were compared with those of autotransplants in the extrahepatic portal bed in splenectomized mice infected with cercariae of Schistosoma mansoni and in splenectomized uninfected controls. By the fifteenth week after transplantation (and tenth week after injection of cercariae) subcutaneous transplants gained 6.5 times and omental transplants 8.2 times more weight in infected animals than corresponding transplants in uninfected animals. Portal pressures averaged 11 to 13 cm of water in infected animals with transplants and 17 cm in those with intact spleens (compared to that of 6 to 7 cm in controls). Hyperplasia of white pulp with increase in germinal center activity characterized transplants as well as intact spleens of infected animals. The results suggest that a) During the first 10 weeks of experimentally induced infection, portal congestion is not the predominant mechanism regulating increased spleen growth; and b) An intact enlarged spleen appears to contribute to elevated portal pressure.
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- ANDRADE Z. A. [Experimental aspects of splenomegaly caused by schistosomiasis]. Rev Inst Med Trop Sao Paulo. 1962 Jul-Aug;4:249–255. [PubMed] [Google Scholar]
- ARAFA M. A., BIBAWI E., RAAFAT A. The portal pressure in hepatic fibrosis associated with bilharziasis. Am J Trop Med Hyg. 1957 Jan;6(1):108–113. doi: 10.4269/ajtmh.1957.6.108. [DOI] [PubMed] [Google Scholar]
- Bloch E. H., Wahab M. F., Warren K. S. In vivo microscopic observations of the pathogenesis and pathophysiology of hepatosplenic schistosomiasis in the mouse liver. Am J Trop Med Hyg. 1972 Sep;21(5):546–557. doi: 10.4269/ajtmh.1972.21.546. [DOI] [PubMed] [Google Scholar]
- CAMERON G. R., BHATTACHARYYA K. K. PORTAL HYPERTENSION IN EXPERIMENTAL SCHISTOSOMIASIS. J Pathol Bacteriol. 1965 Jan;89:1–12. [PubMed] [Google Scholar]
- CHEEVER A. W., WARREN K. S. HEPATIC BLOOD FLOW IN MICE WITH ACUTE HEPATO-SPLENIC SCHISTOSOMIASIS MANSONI. Trans R Soc Trop Med Hyg. 1964 Sep;58:406–412. doi: 10.1016/0035-9203(64)90086-0. [DOI] [PubMed] [Google Scholar]
- Dumont A. E., Becker F. F., Jacob H. S. Regulation of spleen growth in heaptic dysfunction. Ann Surg. 1974 Apr;179(4):465–471. doi: 10.1097/00000658-197404000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dumont A. E., Berman I. R., Stahl W. M., Ring S. M. Significance of an enlarged splenic artery in patients with bleeding varices. Ann Surg. 1972 Apr;175(4):466–471. doi: 10.1097/00000658-197204000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JACOB H. S., MACDONALD R. A., JANDL J. H. REGULATION OF SPLEEN GROWTH AND SEQUESTERING FUNCTION. J Clin Invest. 1963 Sep;42:1476–1490. doi: 10.1172/JCI104832. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WOMACK N. A., PETERS R. M. The significance of splenomegaly in cirrhosis of the liver. Ann Surg. 1961 Jun;153:1006–1019. doi: 10.1097/00000658-196106000-00020. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Warren K. S., Domingo E. O., Cowan R. B. Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. Am J Pathol. 1967 Nov;51(5):735–756. [PMC free article] [PubMed] [Google Scholar]
- Warren K. S., Domingo E. O. Granuloma formation around Schistosoma mansoni, S. HAEMATOBIUM, AND S. japonicum eggs. Size and rate of development, cellular composition, cross-sensitivity, and rate of egg destruction. Am J Trop Med Hyg. 1970 Mar;19(2):292–304. doi: 10.4269/ajtmh.1970.19.292. [DOI] [PubMed] [Google Scholar]
- Warren K. S. The immunopathogenesis of schistosomiasis: a multidisciplinary approach. Trans R Soc Trop Med Hyg. 1972;66(3):417–434. doi: 10.1016/0035-9203(72)90273-8. [DOI] [PubMed] [Google Scholar]