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O6-alkylguanine elimination from bulk DNA of different tissues after exposure to MeNU or EtNU in vivo. DNA was isolated from mammary gland, liver, and brain, at different times after carcinogen exposure. O6-alkylguanine contents in DNA were quantified by ISB. Mean values of duplicate analyses from two (O6-MeGua) or four animals (O6-EtGua) per time point. Error bars: Range of measured values.
