Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1975 Mar;78(3):417–426.

Acute newcastle viral infection of the upper respiratory tract of the chicken. II. The effect of diets deficient in vitamin A on the pathogenesis of the infection.

F B Bang, B G Bang, M Foard
PMCID: PMC1913038  PMID: 1119536

Abstract

Keratotic and squamous changes characteristic of vitamin A deficiency were minimal even in chicks which were malnourished and growth stunted and had no vitamin A in their diet. However, when these chicks were infected with Newcastle disease virus (NDV), keratotic changes appeared, most markedly in areas regenerating after infection. In chicks raised on full nutrient diets lacking only vitamin A, keratotic changes appeared in several areas of nasal mucosa but were absent from the mucosa of the inner (under) surface of the maxillary turbinate. Following NDV infection, such changes did appear in the inner lining epithelia. It is suggested that depletion of vitamin A causes regenerating epithelial cells to keratinize. Other effects of combined lack of vitamin A plus NDV infection were exhaustion of lymphoid cells from cranial bone marrow and exhaustion of lymphoid cell systems locally from the nose and paranasal glands.

Full text

PDF

Images in this article

426Figs 6-9
on p.426
425Figs 1-5
on p.425

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNSTEIN T., BANG F. B. Infection of the upper respiratory tract of the chick with a mild (vaccine) strain of Newcastle disease virus. II. Studies on the pathogenesis of the infection. Bull Johns Hopkins Hosp. 1958 Mar;102(3):135–157. [PubMed] [Google Scholar]
  2. BURNSTEIN T., BANG F. B. Infection of the upper respiratory tract of the chick with a mild (vaccine) strain of Newcastle disease virus: I. Initiation and spread of the infection. Bull Johns Hopkins Hosp. 1958 Mar;102(3):127–134. [PubMed] [Google Scholar]
  3. Bang B. G., Bang F. B., Foard M. A. Lymphocyte depression induced in chickens on diets deficient in vitamin A and other components. Am J Pathol. 1972 Jul;68(1):147–162. [PMC free article] [PubMed] [Google Scholar]
  4. Bang B. G., Bang F. B. Laryngotracheitis virus in chickens. A model for study of acute nonfatal desquamating rhinitis. J Exp Med. 1967 Mar 1;125(3):409–428. doi: 10.1084/jem.125.3.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bang B. G., Bang F. B. Replacement of virus-destroyed epithelium by keratinized squamous cells in vitamin A-deprived chickens. Proc Soc Exp Biol Med. 1969 Oct;132(1):50–54. doi: 10.3181/00379727-132-34146. [DOI] [PubMed] [Google Scholar]
  6. Bang B. G., Foard M. A., Bang F. B. The effect of vitamin A deficiency and Newcastle disease on lymphoid cell systems in chickens. Proc Soc Exp Biol Med. 1973 Sep;143(4):1140–1146. doi: 10.3181/00379727-143-37487. [DOI] [PubMed] [Google Scholar]
  7. Bang F. B., Foard M., Bang B. G. Acute Newcastle viral infection of the upper respiratory tract of the chicken. I. A model for the study of environmental factors on upper respiratory tract infection. Am J Pathol. 1974 Aug;76(2):333–348. [PMC free article] [PubMed] [Google Scholar]
  8. Bro-Jorgensen K., Volkert M. Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 1. The enhanced x-ray sensitivity of virus infected mice. Acta Pathol Microbiol Scand B Microbiol Immunol. 1972;80(6):845–852. doi: 10.1111/j.0365-5563.1973.tb00010.x. [DOI] [PubMed] [Google Scholar]
  9. Gopalan C. A report on the first fifty years of the Nutrition Research Laboratories, Hyderabad. Nutr Rev. 1970 Jan;28(1):1–7. doi: 10.1111/j.1753-4887.1970.tb06140.x. [DOI] [PubMed] [Google Scholar]
  10. Hayes K. C. On the pathophysiology of vitamin A deficiency. Nutr Rev. 1971 Jan;29(1):3–6. doi: 10.1111/j.1753-4887.1971.tb07206.x. [DOI] [PubMed] [Google Scholar]
  11. Kloene W., Bang F. B., Chakraborty S. M., Cooper M. R., Kulemann H., Shah K. V., Ota M. A two-year respiratory virus survey in four villages in West Bengal, India. Am J Epidemiol. 1970 Nov;92(5):307–320. doi: 10.1093/oxfordjournals.aje.a121212. [DOI] [PubMed] [Google Scholar]
  12. OOMEN H. A., MCLAREN D. S., ESCAPINI H. EPIDEMIOLOGY AND PUBLIC HEALTH ASPECTS OF HYPOVITAMINOSIS A. A GLOBAL SURVEY ON XEROPHTHALMIA. Trop Geogr Med. 1964 Dec;16:271–315. [PubMed] [Google Scholar]
  13. Ota W. K., Bang F. B. A continuous study of viruses in the respiratory tract in families of a Calcutta bustee. I. Description of the study area and patterns of virus recovery. Am J Epidemiol. 1972 Apr;95(4):371–383. doi: 10.1093/oxfordjournals.aje.a121406. [DOI] [PubMed] [Google Scholar]
  14. Ota W. K., Bang F. B. A continuous study of viruses in the respiratory tract in families of a Calcutta bustee. II. Family patterns of infection and illness in a crowded environment. Am J Epidemiol. 1972 Apr;95(4):384–391. doi: 10.1093/oxfordjournals.aje.a121407. [DOI] [PubMed] [Google Scholar]
  15. WILHELM D. L. Regeneration of the tracheal epithelium in the vitamin-A-deficient rat. J Pathol Bacteriol. 1954 Apr;67(2):361–365. doi: 10.1002/path.1700670209. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES