Fig. 4.

Performance of both PDAPP and WT mice worsened following experimental controlled cortical impact TBI (P < 0.00001, repeated measures ANOVA). Mice were retested in a different room with the platform in a different location and different spatial cues. Sham-treated mice received anesthesia and a craniotomy but no TBI. Assessments were made blinded to genotype and injury status. Changes in search strategy use largely explain the impaired performance following TBI. Dashed lines represent the predicted performance of PDAPP and WT mice with and without TBI based entirely on search strategy use; the efficacy with which the mice used each of the individual search strategies was held constant. Data from all 4 days of post-TBI hidden platform training were combined for this analysis. (A) PDAPP mice. (B) WT mice.