Table 2.
Performance as a function of strategy use in hidden platform Morris water maze testing
| Strategy | PDAPP day 1 | PDAPP day 5 | PDAPP after sham | PDAPP after TBI | WT day 1 | WT day 5 | WT after sham | WT after TBI |
|---|---|---|---|---|---|---|---|---|
| Repetitive looping | 1152 ± 61
n = 43 |
941 ± 108
n = 14 |
467 ± 59
n = 27 |
859 ± 35
n = 78 |
256 ± 54
n = 4 |
137 ± 48
n = 5 |
89
n = 1 |
401
n = 1 |
| Circling | 1124 ± 73
n = 8 |
476 ± 146
n = 2 |
664 ± 71
n = 5 |
816 ± 112
n = 2 |
N/A | N/A | N/A | 401
n = 1 |
| Peripheral looping | 1293 ± 38
n = 30 |
1386 ± 73
n = 8 |
1354
n = 1 |
1122 ± 27
n = 35 |
N/A | N/A | N/A | N/A |
| Chaining | 354 ± 93
n = 5 |
286 ± 104
n = 4 |
378 ± 35
n = 21 |
636 ± 25
n = 41 |
256 ± 54
n = 4 |
137 ± 48
n = 5 |
89
n = 1 |
N/A |
| Non-spatial, systematic | 747 ± 47
n = 45 |
513 ± 45
n = 48 |
443 ± 26
n = 97 |
668 ± 36
n = 49 |
626 ± 44
n = 37 |
425 ± 96
n = 8 |
450 ± 49
n = 27 |
519 ± 33
n = 61 |
| Random | 824 ± 34
n = 38 |
740 ± 42
n = 24 |
477 ± 28
n = 33 |
710 ± 25
n = 40 |
646 ± 18
n = 34 |
457 ± 44
n = 6 |
552 ± 48
n = 11 |
606 ± 25
n = 41 |
| Scanning | 473
n = 1 |
267 ± 55
n = 14 |
404 ± 21
n = 58 |
523 ± 56
n = 8 |
388 ± 62
n = 3 |
326 ± 76
n = 2 |
364 ± 44
n = 13 |
310 ± 41
n = 15 |
| Focal incorrect | 305 ± 85
n = 6 |
315 ± 66
n = 10 |
462 ± 65
n = 6 |
159
n = 1 |
N/A | N/A | 443 ± 91
n = 3 |
293 ± 71
n = 5 |
| Spatial | 162 ± 10
n = 96 |
166 ± 9
n = 121 |
108 ± 7
n = 132 |
130 ± 9
n = 65 |
143 ± 7
n = 122 |
95 ± 7
n = 153 |
91 ± 7
n = 132 |
145 ± 9
n = 66 |
| Focal correct | 1067
n = 1 |
343 ± 46
n = 20 |
197 ± 56
n = 8 |
298 ± 112
n = 2 |
355 ± 40
n = 7 |
198 ± 44
n = 6 |
214 ± 65
n = 6 |
319 ± 46
n = 12 |
| Spatial indirect | 198 ± 26
n = 65 |
149 ± 24
n = 77 |
140 ± 18
n = 77 |
163 ± 24
n = 43 |
155 ± 13
n = 70 |
116 ± 13
n = 71 |
135 ± 22
n = 52 |
128 ± 25
n = 39 |
| Spatial direct | 54 ± 38
n = 30 |
73 ± 42
n = 24 |
43 ± 23
n = 47 |
43 ± 35
n = 20 |
92 ± 16
n = 45 |
68 ± 12
n = 76 |
50 ± 18
n = 74 |
48 ± 41
n = 15 |
Distance in cm (mean ± standard error). n: number of individual trials during hidden platform testing where a given strategy was used. N/A: not applicable; no examples of this search strategy were found. Shaded rows: classes of strategies. Values reflect the pooled results from the 3 specific strategies listed below each shaded row.