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. Author manuscript; available in PMC: 2008 May 25.

Published in final edited form as: Biochem Biophys Res Commun. 2007 Apr 2;357(1):282–288. doi: 10.1016/j.bbrc.2007.03.143

The metastasis of MDA-MB-231 cells to the bone was studied in buffer- or Eap-treated mice. (A) The total volume (in mm³) of metastases was estimated by volumetric CT and (B) the total metastasis count in vertebrae and extremities was counted at days 21 and 35 after the initial intracardiac injection of MDA-MB-231 cells. Data are mean±SD (n=5 mice/group). (C) Representative CT images from the lower extremities of a buffer-treated mouse and an Eap-treated mouse 35 days after initial intracardiac inoculation of MDA-MB-231 cells. Metastatic osteolytic lesions are depicted by arrows. *: P<0.05, as compared to buffer; **: P<0.01, as compared to buffer.

The metastasis of MDA-MB-231 cells to the bone was studied in buffer- or Eap-treated mice. (A) The total volume (in mm³) of metastases was estimated by volumetric CT and (B) the total metastasis count in vertebrae and extremities was counted at days 21 and 35 after the initial intracardiac injection of MDA-MB-231 cells. Data are mean±SD (n=5 mice/group). (C) Representative CT images from the lower extremities of a buffer-treated mouse and an Eap-treated mouse 35 days after initial intracardiac inoculation of MDA-MB-231 cells. Metastatic osteolytic lesions are depicted by arrows. *: P<0.05, as compared to buffer; **: P<0.01, as compared to buffer.