TABLE 1.
Clinical and antimicrobial profile and molecular information from the clinical isolates harboring blaIMP-1-carrying In86 evaluated in the present study
| Parameter | Value
|
|||||||
|---|---|---|---|---|---|---|---|---|
| A. baumannii 694 | A. baumannii 696 | A. baumannii 9043 | A. baumannii 695 | A. baumannii 501 | Acinetobacter sp. strain 5227 | Acinetobacter sp. strain 5248 | P. putida 12346 | |
| Sample collection date (mo/day/yr) | 05/28/2002 | 06/04/2002 | 06/22/2001 | 06/02/2002 | 05/06/2001 | 08/14/2002 | 09/28/2002 | 07/23/2001 |
| Source | SSTIb | SSTIb | BSIc | SSTIb | BSIc | LRTId | LRTId | BSIc |
| MIC (μg/ml)a | ||||||||
| β-Lactam | ||||||||
| Aztreonam | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Ampicillin | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Amoxicillin-clavulanate | >16 | >16 | >16 | >16 | 16 | >16 | >16 | >16 |
| Aztreonam | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Ceftazidime | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Piperacillin | >128 | >128 | >128 | 128 | 32 | >128 | >128 | 64 |
| Piperacillin-tazobactam | 32 | 64 | >64 | 64 | 64 | >64 | 64 | 64 |
| Ticarcillin | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 |
| Ticarcillin-clavulanate | >128 | >128 | >128 | >128 | >128 | >128 | >128 | >128 |
| Cefepime | >16 | >16 | >16 | >16 | >16 | >16 | >16 | >16 |
| Imipenem | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Meropenem | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Aminoglycoside | ||||||||
| Amikacin | >32 | >32 | >32 | 32 | 32 | >32 | 32 | >32 |
| Gentamicin | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Netilmycin | 32 | 32 | >32 | 8 | >32 | >32 | 16 | >32 |
| Tobramycin | 16 | 16 | 16 | >16 | >16 | 16 | 8 | >16 |
| Quinolone | ||||||||
| Levofloxacin | 0.25 | 0.25 | >4 | >4 | 0.25 | 2 | 4 | >4 |
| Gatifloxacin | 0.25 | 0.06 | >4 | 4 | 0.12 | 1 | 4 | >4 |
| Ciprofloxacin | 1 | 0.5 | >2 | >4 | 0.12 | 2 | >4 | >2 |
| Polymyxin B | ≤1 | ≤1 | ≤1 | ≤1 | ≤1 | ≤1 | ≤1 | ≤1 |
| blaIMP-1 location | Plasmidial | Plasmidial | Plasmidial | Plasmidial | Plasmidial | Chromosomal | Plasmidial | Chromosomal |
| Ribotyping | 258.105.2 | 258.105.2 | 105.815.4 | 105.815.4 | 252.43.4 | 258.148.6 | 258.148.2 | NAe |
| PFGE | PSA48A | PSA48A | PSA48B | PSA48B1 | PSA48C | PSA48D | PSA48E | NAe |
a
Interpretive criteria for the antimicrobial tested were those published by the Clinical and Laboratory Standard Institute (CLSI) (formerly National Committee for Clinical Laboratory Standards) (4).
b
SSTI, skin and soft tissue infection.
c
BSI, bloodstream infection.
d
LRTI, lower respiratory tract infection.
e
NA, not applicable.