TABLE 5.
Variable | No. of patients with variable/total no. of patients (%)
|
OR (95% CI) | P value | |
---|---|---|---|---|
Survivors (n = 205) | Nonsurvivors (n = 28) | |||
Integron | ||||
Yes | 62/73 (84.9) | 11/73 (15.1) | 1.49 (0.66-3.37) | 0.386 |
No | 143/160 (89.4) | 17/160 (10.6) | ||
Size of integron (bp) | ||||
≥1,800 | 20/23 (87) | 3/23 (13) | 0.58 (0.14-2.46) | 0.516 |
<1,800 | 31/39 (79.5) | 8/39 (20.5) | ||
Extended-spectrum β-lactamase production | ||||
Yes | 19/23 (82.6) | 4/23 (17.4) | 1.63 (0.51-5.20) | 0.494 |
No | 186/210 (88.6) | 24/210 (11.4) | ||
VIM production | ||||
Yes | 6/9 (66.7) | 3/9 (33.3) | 3.98 (0.94-16.92) | 0.045 |
No | 202/228 (88.6) | 26/228 (11.4) | ||
Multidrug resistancea | ||||
Yes | 75/91 (82.4) | 16/91 (17.6) | 2.31 (1.04-5.15) | 0.041 |
No | 130/142 (91.5) | 12/142 (8.5) | ||
Bacterial species | 0.161 | |||
E. coli | 129/142 (90.8) | 13/142 (9.2) | 1 | |
K. pneumoniae | 39/45 (86.7) | 6/45 (13.3) | 1.53 (0.54-4.28) | 0.421 |
Other | 37/46 (80.4) | 9/46 (19.6) | 2.41 (0.96-6.09) | 0.062 |
Severity of underlying diseaseb | 0.477 | |||
Nonfatal | 59/64 (92.2) | 5/64 (7.8) | 1 | |
Ultimately fatal | 115/133 (86.5) | 18/133 (13.5) | 1.85 (0.65-5.22) | 0.247 |
Rapidly fatal | 31/36 (86.1) | 5/36 (13.9) | 1.90 (0.51-7.08) | 0.337 |
Pitt bacteremia score | ||||
≥4 | 32/52 (61.5) | 20/52 (38.5) | 13.51 (5.48-33.32) | <0.001 |
<4 | 173/181 (95.6) | 8/181 (4.4) | ||
Source of bacteremia | 0.004 | |||
Urinary tract | 109/112 (97.3) | 3/112 (2.7) | 1 | |
Unknown | 43/57 (75.4) | 14/57 (24.6) | 11.83 (3.23-43.23) | <0.001 |
Abdomen | 37/42 (88.1) | 5/42 (11.9) | 4.91 (1.12-21.55) | 0.035 |
Intravenous catheter | 6/9 (66.7) | 3/9 (33.3) | 18.17 (3.01-109.79) | 0.002 |
Soft tissue | 5/7 (71.4) | 2/7 (28.6) | 14.53 (1.96-107.51) | 0.009 |
Lung | 5/6 (83.3) | 1/6 (16.7) | 7.27 (0.64-82-89) | 0.110 |
Immunosuppression | ||||
Yes | 76/85 (89.4) | 9/85 (10.6) | 0.80 (0.35-1.87) | 0.680 |
No | 129/148 (87.2) | 19/148 (12.8) | ||
Nosocomial infection | ||||
Yes | 83/98 (84.7) | 15/98 (15.3) | 1.70 (0.77-3.75) | 0.223 |
No | 122/135 (90.4) | 13/135 (9.6) | ||
Appropriate antibiotic therapy | ||||
Yes | 182/207 (87.9) | 25/207 (12.1) | 0.95 (0.27-3.39) | 1.000 |
No | 23/26 (88.5) | 3/26 (11.5) |
Resistance to three or more classes of antimicrobial agents.
As classified by McCabe and Jackson (15). When in-hospital mortality was used as an end point, the severity of underlying disease was an independent factor associated with mortality.