FIG. 6.

Body weights of mice treated with PMOs or PPMOs. Six-week-old C3H female mice were treated, weighed, and observed daily. Averages of the percentages of original weights are shown, and error bars represent standard deviations of ±1. (A) Mice were inoculated i.p. daily with the vehicle alone (n = 4) or 3 mg of the scramble PMO (n = 8) for seven treatments. The solid arrow indicates the last day of treatment. (B) Mice were inoculated i.p. daily with the vehicle alone (n = 4) for nine treatments, 200 μg of the scramble PPMO (n = 8) for nine treatments, or 300 μg of the scramble PPMO (n = 8) for five treatments. The solid arrow indicates the last day of treatment for groups receiving the vehicle alone and 200 μg of the scramble PPMO. The hollow arrow indicates the last day of treatment for the group receiving 300 μg of the scramble PPMO, which was discontinued after only five treatments due to an average loss among the animals of more than 5% of body weight.