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Unconjugated PMOs do not protect mice from WNV disease. Six-week-old C3H female mice were inoculated s.c. in the left rear footpad with 103 PFU of WNV on day 0. Groups of eight mice were treated with 3 mg of the 5′-end PMO, 3 mg of the 3′ CSI PMO, 3 mg of the scramble PMO, or the vehicle alone. Treatments were administered i.p. daily on days 0 to 6.
