TABLE 2.
Weights of organs after PMO and PPMO treatment did not differ from those from vehicle-treated controlsa
| Treatment | No. of mice | Dose | No. of days treated | Avg wt (g) (SD) of:
|
|||||
|---|---|---|---|---|---|---|---|---|---|
| Brains | Hearts | Lungs | Livers | Spleens | Kidneys | ||||
| Vehicle | 4 | NA | 7 | 0.40 (0.02) | 0.09 (0.01) | 0.11 (0.04) | 1.02 (0.04) | 0.06 (0.01) | 0.26 (0.01) |
| Scramble PMO | 8 | 3 mg | 7 | 0.41 (0.02) | 0.09 (0.01) | 0.12 (0.02) | 1.05 (0.10) | 0.06 (0.01) | 0.24 (0.03) |
| Vehicle | 4 | NA | 9 | 0.38 (0.02) | 0.11 (0.02) | 0.13 (0.02) | 1.11 (0.09) | 0.07 (0.02) | 0.24 (0.03) |
| Scramble PPMO | 8 | 200 μg | 9 | 0.38 (0.02) | 0.09 (0.03) | 0.12 (0.02) | 1.16 (0.12) | 0.13 (0.06) | 0.27 (0.03) |
a
Six-week-old C3H female mice were treated i.p. daily for 7 or 9 days. Two days after the end of treatment, all mice were sacrificed, and the entire brain, heart, lung, liver, and spleen and both kidneys of each mouse were weighed. NA, not applicable. No statistical differences between the drug- and vehicle-treated groups were observed.