TABLE 3.

Steady-state pharmacokinetics of pyrazinamide and ethambutol^a

Parameter	Value at rifampin dose (mg):		600-mg/450-mg ratio (geometric mean + 95% CIb)	P value
	600 (n = 23)	450 (n = 24)
Pyrazinamide
AUC0-24 (mg·h/liter)	514.5 (266.4-775.3)	472.8 (258.9-705.1)	1.04 (0.93-1.27)	0.269c
Cmax (mg/liter)	46.0 (23.3-71.8)	43.8 (19.2-62.1)	1.05 (0.91-1.21)	0.493c
Tmax (h) [median (range)]	2.5 (2-6)	2.75 (1-6)		0.897d
t1/2 (h)	6.9 (4.1-11.7)	6.6 (3.9-12.7)	1.04 (0.89-1.22)	0.593c
Ethambutol
AUC0-24 (mg·h/liter)	14.7 (10.0-23.4)	14.4 (9.6-22.5)	1.02 (0.88-1.17)	0.830c
Cmax (mg/liter)	2.3 (1.2-5.6)	2.4 (1.1-4.9)	0.98 (0.77-1.24)	0.863c
Tmax (h) [median (range)]	2.5 (1.5-4)	2.5 (1.5-6)		0.397d
t1/2 (h)	4.6 (1.8-6.8)	4.2 (2.6-5.5)	1.09 (0.95-1.24)	0.217c

^aAfter daily administration of 1,500 mg (30 mg/kg) and 750 mg (15 mg/kg) (geometric mean plus range, unless stated otherwise).

^bCI, confidence interval.

^cIndependent t test on log-transformed data.

^dWilcoxon rank sum test.