TABLE 2.
Changes in amino acid sequences of LMV-resistant rt during treatment
| Change and case no. | Genotype | Initial change(s) | Subsequent change(s)a | Elapsed time (mo)b | HBV DNA changec |
|---|---|---|---|---|---|
| Gain of L80I or L80V | |||||
| 52 | B | M204I | +L80V+L180M; M204I→V | 22 | 40 |
| 59 | D | M204I | +L80V+L180M | 31 | 0.4 |
| 225 | C | M204V | +L80V+L180M | 11 | 0.03 |
| 301 | C | M204I | +L80I+L180M | 4 | 0.5 |
| 375 | C | M204I | +L80V | 16 | 3.6 |
| 550 | D | L180M/M204V | +L80V | 13 | 2.0 |
| Loss of L80I | |||||
| 333 | D | L80I/M204V | −L80I; M204V→I | 4 | 0.05 |
| 953 | C | L80I/M204I | −L80I | 15 | NA |
| Change L80V→L80I | |||||
| 267 | B | L80V/L180M/M204V | L80V→I | 8 | 2.2 |
| 872 | D | L80V/L180M/M204I | L80V→I | 2 | 1.8 |
| Gain of L180M | |||||
| 57 | B | M204I | +L180M; M204I→V | 14 | 4.8 |
| 120 | A | M204I | +L180M | 5 | NC |
| 172 | A | M204I | +L180M; M204I→V | 7 | NA |
| 187 | A | M204I | +L180M; M204I→V | 58 | 1.2 |
| 192 | D | M204I | +L180M | 6 | NC |
| 214 | A | M204I | +L180M; M204I→V | 7 | 3.6 |
| 277 | D | L80I/M204I | +L180M | 2 | 1,164 |
| 332 | C | L80I/M204I | +L180M; M204I→V | 39 | 0.7 |
| 1316 | B | L80I/M204I | +L180M | 5 | 29.1 |
| Change M204V→M204I | |||||
| 5 | D | L80I/L180M/M204V | M204V→I | 11 | 6.6 |
| 555 | C | L180M/M204V | M204V→I | 19 | NA |
a
Changes listed in the “initial change(s)” column were maintained unless indicated otherwise in the “subsequent change(s)” column.
b
Elapsed time between sampling for isolates in which changes were detected.
c
Fold change in viral load (as serum HBV DNA load) associated with rt change; NC, no change (low, stable viremia); NA, not available. Note that L80I/V appears after the acquisition of primary LMV resistance.