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Dixon plots for 5-Cl-PZA (A) and pyrazinamide (B) inhibition of FASI. The results are indicative of competitive inhibition of NADPH oxidation, with Kis of 55 to 59 μM and 2,567 to 2,627 μM, respectively. Results were obtained from spectrometric assays using cell extracts of FASI (3 μg/ml).
