TABLE 2.

IC₅₀s and IC₉₀s of lignans, alone or in mixtures, tested against P. falciparum isolate BHz26/86

Lignan(s)	Compound	IC50 (μM)a	IC90 (μM)a
1	(7′R,8S,8′R)-4,5-Dimethoxy-3′,4′-methylenodioxy-2,7′-cyclolignan-7-one	0.26 ± 0.08	3.35 ± 0.12
2	(7′R,8S,8′R)-3′,4,4′,5-Tetramethoxy-2,7′-cyclolignan-7-one	0.32 ± 0.11	4.60 ± 0.30
3	(7′R,8R,8′S)-3′,4,4′,5-Tetramethoxy-2,7′-cyclolignan-7-one	0.20 ± 0.09	3.00 ± 0.15
4	(7′R,8S,8′S)-3′,4,4′,5-Tetramethoxy-2,7′-cyclolignan-7-one	0.63 ± 0.20	2.61 ± 0.06
5	(7′R,8S,8′S)-3′,4′-Dimethoxy-4,5-methylenodioxy-2,7′-cyclolignan-7-one	8.00 ± 0.65	19.70 ± 0.42
6	(7′R,8S,8′S)-4,5-Dimethoxy-3′,4′-methylenodioxy-2,7′-cyclolignan-7-one	>140.00	>140.00
3 + 4	Combination (3:8)	2.80 ± 0.34	9.13 ± 0.30
2 + 3 + 4	Combination (3:1:2)	6.00 ± 0.50	18.20 ± 0.40
1 + 5 + 6	Combination (11:3:2)	1.90 ± 0.09	8.40 ± 0.15
	Chloroquineb	0.19 ± 0.02	0.70 ± 0.13

^aValues are means ± standard deviations in triplicate.

^bAntimalarial reference drug.