TABLE 1.
Genes under the control of T. thermophilus CRP-dependent promoters and their expression in the T. thermophilus ΔCRP strain relative to that in the wild type
| Gene name | COG no. | Annotation for producta | Expressionb (q value) at time (h)
|
|
|---|---|---|---|---|
| 6 | 8 | |||
| TTHA0176 | 1670/1247 | GCN5-related acetyltransferase | 0.772 (0.069) | 0.652 (0.107) |
| TTHA0771 | 3629 | Transcriptional activator of the SARP family | 0.291 (0.023) | 0.161 (0.106) |
| TTHB147 | 1353 | Novel DNA polymerase, Csm1 family | 0.271 (0.015) | 0.149 (0.043) |
| TTHB148 | 1421 | No prediction, Csm2 family | 0.260 (0.015) | 0.190 (0.036) |
| TTHB149 | 1337 | RAMP superfamily, Csm3 | 0.269 (0.007) | 0.294 (0.107) |
| TTHB150 | 1567 | RAMP superfamily, Csm4 | 0.302 (0.047) | 0.156 (0.020) |
| TTHB151 | 1332 | RAMP superfamily, Csm5 | 0.342 (0.013) | 0.160 (0.036) |
| TTHB152 | No prediction | 0.398 (0.012) | 0.260 (0.043) | |
| TTHB156 | No prediction | 0.030 (0.023) | 0.074 (0.073) | |
| TTHB157 | No prediction | 0.018 (0.021) | 0.031 (0.132) | |
| TTHB158 | No prediction | 0.037 (0.061) | 0.052 (0.017) | |
| TTHB159 | No prediction | 0.596 (0.014) | 0.620 (0.180) | |
| TTHB178 | 2176 | Exonuclease III domain | 0.154 (0.023) | 0.115 (0.012) |
| TTHB186 | 2378 | Predicted transcriptional regulator | 0.063 (0.018) | 0.043 (0.012) |
| TTHB187 | 1203 | CRISPR-associated helicase, Cas3 family | 0.101 (0.007) | 0.069 (0.020) |
| TTHB188 | Cse1 family | 0.252 (0.012) | 0.176 (0.020) | |
| TTHB189 | Cse2 family | 0.191 (0.012) | 0.159 (0.036) | |
| TTHB190 | Cse4 family | 0.241 (0.014) | 0.173 (0.036) | |
| TTHB191 | Cse5e family | 0.219 (0.030) | 0.178 (0.036) | |
| TTHB192 | Cse3 family | 0.159 (0.012) | 0.146 (0.037) | |
| TTHB193 | 1518 | Novel nuclease, Cas1 family | 0.193 (0.012) | 0.143 (0.016) |
| TTHB194 | Cas2 family | 0.293 (0.022) | 0.176 (0.020) | |
a
The annotations for the TTHA0771, TTHB178, and TTHB186 gene products are cited from the descriptions of the corresponding COG families, and those for the TTHA0176, TTHB188, TTHB189, TTHB190, TTHB191, TTHB192, and TTHB194 gene products are from the results of a PSI-BLAST search. The others are cited from Makarova et al. (37, 38), Haft et al. (18), Omelchenko et al. (45), and Brüggemann and Chen (4).
b
Normalized intensity in the ΔCRP strain relative to that in the wild type.