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. 2007 Mar 23;189(11):4265–4274. doi: 10.1128/JB.00011-07

FIG. 2.

FIG. 2.

Expression profile of M. tuberculosis in mice during chronic and reactivation stages of infection. (A) A two-dimensional hierarchical cluster analysis of expression levels of M. tuberculosis H37Rv genes growing in 7H9 Middlebrook broth or in BALB/c mice at different times after aerosol infection (28, 45, and 60 days p.i.). One example of a gene cluster with down-regulated genes in all in vivo samples is presented. (B) A two-dimensional hierarchical cluster analysis of gene expression levels of M. tuberculosis growing in 7H9 Middlebrook broth or in BALB/c mice at 28, 45, 52, and 60 days p.i. One example of a cluster with up-regulated genes in all in vivo samples is presented. The red and green boxes denote up- or down-regulation, respectively.