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Rapamycin biosynthetic gene cluster, showing the location and the area of deletion of the rapH and rapG genes. Promoter PrapA, which controls the main PKS operon rapA-rapB, is also shown. To the right side of the rapA-rapB operon lie genes encoding RapP, a pipecolate-incorporating enzyme, and RapC, which together with RapA and RapB represent the rapamycin PKS.
