TABLE 3.

Proteins similar to RapH and RapG

Proteina	% Identity	% Similarity	System regulated	Organism	Reference
RapH homologues
FkbN	59	71	FK520 PKS	S. hygroscopicus subsp. ascomyceticus	48
PikD	33	45	Pikromycin PKS	Streptomyces venezuelae	47
GdmRII	36	49	Geldanamycin PKS	S. hygroscopicus NRRL 3602	35
HbmRII	36	49	Herbimycin PKS	S. hygroscopicus AM-3672	34
NbmM	33	45	Desosamine biosynthesis	Streptomyces narbonensis	7
MonH	34	44	Monensin PKS	Streptomyces cinnamonensis	31
RapG homologues
SCO7780	50	61	Unknown	Streptomyces coelicolor A3(2)	2
NitR	33	50	Nitrilase	Rhodococcus rhodochrous	27
FasR	34	58	Leafy gall formation	Rhodococcus fascians	43
FeaR	29	50	2-Phenylethylamine catabolism	Escherichia coli	21

^aAll of the identified proteins similar to RapH belong to the LAL family of Streptomyces regulators, with their characteristic LuxR-type pattern of an HTH DNA-binding motif at the C terminus and a P loop distinctive of an ATP-binding site at the N terminus, while all of the identified proteins similar to RapG contain the AraC-like HTH DNA-binding motif at the C-terminal region.