TGF-β receptor |
bone morphogenic protein receptor type I (Sus nr/Macaca est) |
OvAE22 |
44 |
Seven transmembrane receptor |
DC-STAMP (Strongylocentrotus); laminin receptor (Bos nr/Clonorchis est) |
OvAE92, OvAE1722 |
51 |
Tetraspanin |
stabilize cell membranes – expressed in the tegument of schistosomes (Schistosoma) |
OvAE953 |
34 |
C1 family papain-like cysteine protease |
cathepsin L (Paragonimus), cathepsin B (Fasciola; Clonorchis) |
OvAE1795, OvAE813, OvAE1171, OvAE532, OvAE1070, OvAE1613, OvAE1711, OvAE615, OvAE398 |
> 80 |
C13 family asparaginyl endopeptidase |
legumain (O. viverrini) |
OvAE1624, OvAE1824 |
94 |
S1 family serine protease |
HtrA-like (Macaca nr/Schistosoma est) and kallikrein-like (Schistosoma) peptidases |
OvAE622, OvAE1918 |
47–53 |
A1 family aspartic protease |
cathepsin D-like; digestive enzyme in helminths (Clonorchis) |
OvAE1300 |
80 |
M41 family metalloprotease |
mitochondrial membrane proteinase (Schistosoma) |
OvAE65 |
91 |
Granulin |
mitogen associated with cancer (Bos nr/Clonorchis est) |
OvAE1732 |
45 |
Aquaporin |
water channel protein (Schistosoma) |
OvAE6 |
48 |
Tyrosinase |
critical for S. mansoni egg shell production (Schistosoma) |
OvAE1900, OvAE1854 |
63 |
Phospholipase A2 |
similar to vertebrate venom proteins; (Heloderma nr/Clonorchis est) |
OvAE1644 |
55 |
Thioredoxin peroxidase |
immunomodulatory in fasciolosis (Schistosoma) |
OvAE54 |
74 |
EF-hand secreted Ca2+-binding protein |
calumenin (Rattus nr/Xenopus est) |
OvAE61 |
47 |
Saposin-like protein |
pore forming; similar to fluke cytolysins (Clonorchis) |
OvAE1692 |
64 |
Pathogenesis related protein |
similar to helminth venom allergen homologues (Schistosoma) |
OvAE534, OvAE1862 |
38 |
Glutathione-S-transferase |
detoxification of heme and free radicals (Clonorchis) |
OvAE1057, OvAE1892, OvAE1601, OvAE1729 |
86 |
Synaptobrevin |
neurotransmission/vesicular docking – vesicle associated (Schistosoma) |
OvAE1001 |
73 |
Innexin |
integral membrane protein forming gap junctions (Schistosoma) |
OvAE631 |
78 |
Fibroblast growth factor (FGF) receptor substrate 2 |
host FGF is essential for growth of schistosomes (Schistosoma) |
OvAE1563 |
32 |
Ly6c |
Immune cell differentiation antigen |
OvAE82 |
26 |