Figure 4.

Model of the C-Terminal Section of CLSY1 Based on Similarity with Rad54.

(A) The crystal structure of Rad54 (Thoma et al., 2005) is superimposed on the predicted structure for the C-terminal domain of CLSY1 as a SwissPDB image. Rad54 is shown in yellow (coils), orange (α-helices), and blue (β-sheets), while CLSY1 is indicated in white (coils), red (α-helices), and green (β-sheets). Variant loops in the DNA binding region are indicated by arrows, with the loop specified by the blue arrow specific to CLSY1 and CLSY2.

(B) The predicted structure for CLSY1 is shown with DNA in the putative binding cleft. The side chains of some basic residues that may contribute to DNA binding are shown in a stick model.