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. 2007 Jul 2;104(28):11649–11654. doi: 10.1073/pnas.0703976104

Fig. 3.

Fig. 3.

Bcl-2 inhibits mitochondrial fragmentation in Bax-knockout cells but not in Bak-knockout cells. MEF cells of different genotypes wild-type (A), Bax-knockout (B), Bak-knockout (C), and Bax/Bak double knockout (D) were transfected with MitoRed alone (NA) or cotransfected with MitoRed and Bcl-2 (Bcl-2). The cells were then subjected to apoptotic treatment with 1 μM STS. Mitochondrial fragmentation was examined by fluorescence and confocal microscopy and quantified by cell counting. Data are means ± SD of three separate experiments. ∗, significant difference between the nontransfected NA group and the Bcl-2-transfected group.