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. 2007 Jul 5;104(28):11518–11525. doi: 10.1073/pnas.0704618104

Fig. 2.

Fig. 2.

Regulation of elements from the CHOP gene by selected factors. (A) Schematic alignment of DNA sequences of conserved regions of the insulin gene promoter and CHOP gene promoter/intron I and relative DNA-binding sites for bZIP transcription factors. The boxed region is the NFAT consensus. The shaded regions indicate MARE consensus sequences. Underlined sequences include C/EBP-β and ATF-CRE sites. (B and C) Promoter–reporter assays of CHOP gene promoter regions 3× −320 to −300 bp (B) and +2,624 to +2,643 bp (C) in Min6 cells maintained in 25 mM glucose overexpressing indicated bZIP transcription factors. V, vector only; M, MafA; A, Atf-2; C, C/EBPβ; F, c-Fos; J, c-Jun. Promoter assays were repeated a minimum of three times.