Table 1.

Effects of glucose and MAPK inhibition on CHOP

Glucose, mM	Islets		Islets/cells	Cell lines
	Promoter binding	Intron binding	Protein	Promoter assay	Intron assay
5.5	Less Maf	More Maf	High	High	High
25/16	More Maf	Less Maf	Low	Low	High
5.5 + U0126	Inhibition	Inhibition	Reduction	No change	Low
25 + U0126	Inhibition	Inhibition	Increase	High	Low