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Varenicline decreased ethanol but not sucrose seeking. Varenicline (0.3–2 mg/kg s.c.) was administered 30 min before the start of the session. One and 2 mg/kg significantly and dose-dependently inhibited active lever presses for 10% ethanol (A) but not 5% sucrose (B). The values are expressed as mean no. of active lever presses ± SEM (repeated measures ANOVA followed by Newman–Keuls post hoc test). *, P < 0.05; **, P < 0.01 compared with vehicle, n = 7–8.
