Table 2.

Varenicline treatment increased water and total fluid intake 24 h after the injection in rats that consumed high amounts of ethanol (intermittent access to 20% ethanol)

Varenicline, mg/kg	Time after onset of drinking
	6 h		24 h
	Water, ml	Total fluid, ml	Water, ml	Total fluid, ml
0.3	16 ± 4	26 ± 4	28 ± 5*	45 ± 5*
1	14 ± 4	21 ± 4	27 ± 5**	43 ± 4
2	11 ± 3	17 ± 3	26 ± 5*	40 ± 5
Vehicle	9 ± 1	20 ± 1	18 ± 2	38 ± 2

The values are expressed as mean fluid intake ± SEM (repeated-measures ANOVA followed by Newman–Keuls post hoc test).

*, P < 0.05;

**, P < 0.01 compared with vehicle; n = 8.