Table 1.
Predicted clusters of readthrough proteins
| Cluster description | Codon | Size | Example organism (locus) |
| Selenocysteine | |||
| Formate dehydrogenase α subunit | TGA | 45 | Escherichia coli (b1474) |
| Selenide water dikinase | TGA | 12 | Haemophilus influenzae (HI0200m) |
| Glycine reductase complex selenoprotein A | TGA | 6 | Treponema denticola (TDE0745) |
| Glycine reductase complex selenoprotein B | TGA | 6 | Treponema denticola (TDE0078) |
| Heterodisulfide reductase subunit A | TGA | 6 | Methanococcus jannaschii (MJ1190m) |
| Coenzyme F420-reducing hydrogenase δ subunit | TGA | 5 | Methanococcus jannaschii (MJ1190a) |
| Formylmethanofuran dehydrogenase subunit B | TGA | 4 | Methanococcus jannaschii (MJ1194m) |
| Glutaredoxin-like | TGA | 3 | Carboxydothermus hydrogenoformans (CHY_0740) |
| Thioredoxin | TGA | 3 | Geobacter sulfurreducens (GSU3446) |
| Coenzyme F420-reducing hydrogenase α subunit | TGA | 3 | Methanococcus jannaschii (MJ0029) |
| HesB family | TGA | 3 | Desulfovibrio vulgaris (DVU_1382) |
| HesB family | TGA | 2 | Methanococcus maripaludis (MMP0252 + upstream) |
| Fe-S oxidoreductase | TGA | 2 | Desulfotalea psychrophila (DP1009) |
| DsbA-like | TGA | 2 | Desulfovibrio desulfuricans (Dde_1263 + upstream) |
| Periplasmic [NiFeSe] hydrogenase large subunit | TGA | 2 | Desulfovibrio vulgaris (DVU_1918) |
| Pyrrolysine | |||
| Monomethylamine methyltransferase | TAG | 7 | Methanosarcina acetivorans (MA0144) |
| Dimethylamine methyltransferase | TAG | 7 | Methanosarcina acetivorans (MA0532) |
| Trimethylamine methyltransferase | TAG | 6 | Methanosarcina acetivorans (MA0528) |
| Transcriptional regulator, TetR family | TAG | 2 | Methanosarcina acetivorans (MA2902) |
| Unknown | |||
| Cytochrome c family protein | TGA | 2 | Geobacter sulfurreducens (GSU2937 + GSU2936) |
| Hypothetical protein | TAG | 2 | Geobacter sulfurreducens (GSU2293 + downstream) |
A plus sign in a locus indicates that the genomic coordinates of the iORF can be described by a concatenation of two genes or regions. For example, "GSU2293 + downstream" means that the iORF consists of the gene GSU2293 and its downstream sequence. HesB family was not clustered into one family, because their sequences were too short and diverged.