Table 1.
Amino Acid Sequences of αA- and κA-Conotoxins. O = hydroxyproline, # = amidation, Z = pyroglutamate, X = gamma-carboxyglutamate, Underlined amino acids are glycosylated. Cysteine residues are in bold text to highlight the shared Cys pattern of these conotoxin subfamilies.
| Toxin Name | Amino Acid Sequence |
|---|---|
| Long αA-Conotoxins | |
| αA-EIVA (Jacobsen et al., 1997) | GCCGPYONAACHOCGCKVGROOYCDROSGG# |
| αA-PIVA (Hopkins et al., 1995) | GCCGSYONAACHOCSCKDROSYCGQ# |
| Short αA-Conotoxins | |
| αA-OIVA (Teichert et al., 2004) | CCGVONAACHOCVCKNTC# |
| αA-OIVB (Teichert et al., 2005) | CCGVONAACPOCVCNKTCG# |
| Long κA-Conotoxins | |
| κA-SIVA (Craig et al., 1998) | ZKSLVPSVITTCCGYDOGTMCOOCRCTNSC# |
| κA-MIVA (Santos et al., 2004) | AOXLVVTATTNCCGYNOMTICOOCMCTYSCOOKRKO# |
| Short κA-Conotoxins | |
| κA-PIVE | DCCGVKLEMCHPCLCDNSCKNYGK# |
| κA-PIVF | DCCGVKLEMCHPCLCDNSCKKSGK# |