Table 2.

BMD measurements by COLIA1 genotypes at baseline and follow-up

	Promoter -1997 G/T				Intron 1 Sp1 G/T
	GG	GT	TT	P*	GG	GT	TT	P*
Men	n = 1,663	n = 494	n = 37		n = 1,484	n = 655	n = 55
Femoral neck (g/cm2)	0.92 ± 0.13	0.92 ± 0.14	0.90 ± 0.14	1.00	0.92 ± 0.14	0.92 ± 0.14	0.90 ± 0.12	0.45
Lumbar spine (g/cm2)	1.16 ± 0.19	1.17 ± 0.20	1.15 ± 0.22	0.96	1.17 ± 0.19	1.16 ± 0.20	1.16 ± 0.20	0.91
Number	n = 668	n = 233	n = 16		n = 606	n = 293	n = 18
FN-BMD change (relative % of baseline year)	−0.46 ± 0.91	−0.36 ± 0.93	−0.38 ± 0.60	0.62	−0.39 ± 0.93	−0.56 ± 0.87	−0.30 ± 0.82	0.01
Women	n = 2,157	n = 710	n = 53		n = 1,971	n = 858	n = 91
Femoral neck (g/cm2)	0.83 ± 0.14	0.84 ± 0.13	0.85 ± 0.13	0. 22	0.83 ± 0.13	0.82 ± 0.14	0.80 ± 0.14	0.09**
Lumbar spine (g/cm2)	1.03 ± 0.18	1.04 ± 0.18	1.01 ± 0.18	0.69	1.04 ± 0.18	1.04 ± 0.19	1.01 ± 0.20	0.52
Number	n = 820	n = 298	n = 24		n = 773	n = 340	n = 29
FN-BMD change (relative % of baseline year)	−0.84 ± 1.11	−0.83 ± 1.01	−0.78 ± 1.03	0.85	−0.85 ± 1.08	−0.80 ± 1.04	−0.74 ± 1.49	0.55

Values are expressed as mean ± SD. Adjustments for age and BMI. Femoral neck (FN) BMD change was measured between second follow-up and baseline

^*P for ANOVA. ^**For trend linear regression: P = 0.03