Fig. 8.

Diffuse myocardial uptake of ^99mTc-labelled Anx A5 in cardiac allograft. Patient 10 underwent Anx A5 imaging 9 months after orthotopic heart transplantation. SPECT imaging 3 h after intravenous injection of radiolabelled Anx A5 demonstrated multifocal myocardial uptake of radiotracer. Smoothing of the images and cardiac SPECT processing in the short axis, vertical long axis and horizontal long axis revealed myocardial perfusion scan-like images with diffuse uptake in the whole myocardium, suggesting apoptosis in the myocardium. Adapted by permission from Macmillan Publishers Ltd: Nature Medicine [42], copyright 2001