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Spline visualization of cumulative dose among current ß -blocker users, stratified according to patients not having (A) or having a history of other antihypertensive drugs (B) (GPRD, dashed line, solid circles; PHARMO RLS, solid line, open circles). Cumulative dose is expressed in DDDs (1,000 DDDs are equivalent to 150 g of metoprolol). Odds ratios were adjusted for the same confounders as in Table 2, except for the use of antihypertensive drugs.
