TABLE 3.

Univariate and multivariate Cox regression analysis of disease-free survival and overall survival according to diagnostic biopsy type

	Disease Free Survival				Overall Survival
	Univariate	Multivariate			Univariate	Multivariate
Tested variables	P	HR	95% CI	P	P	HR	95% CI	P
Diagnostic biopsy type
Wide excision biopsy	0.691	1.00	–	0.204	0.500	1.00	–	0.765
Narrow excision biopsy	0.360	0.71	0.39–1.28	0.255	0.315	0.74	0.37–1.51	0.411
Excision biopsy with positive margins	0.870	0.59	0.29–1.18	0.132	0.748	0.75	0.34–1.65	0.476
Incision biopsy	0.581	0.47	0.19–1.16	0.101	0.387	0.74	0.29–1.89	0.530
Gender	0.018	1.15	0.70–1.89	0.573	0.004	1.44	0.81–2.57	0.215
Age (years)	0.004	1.02	1.00–1.04	0.018	0.002	1.03	1.01–1.05	0.007
Site of primary melanoma
Lower extremity	0.091	1.00	–	0.023	0.153
Upper extremity	0.825	0.91	0.41–2.01	0.809	0.071
Head/Neck	0.014	3.40	1.45–7.97	0.005	0.095
Trunk	0.731	0.93	0.54–1.61	0.790	0.063
Breslow thickness (mm)
0 < x ≤ 1	<0.001	1.00	–	<0.001	<0.001	1.00	–	0.001
1 < x ≤ 2	0.003	13.19	1.77–98.41	0.012	0.016	8.15	1.07–62.19	0.043
2 < x ≤ 4	<0.001	34.11	4.50–258.60	0.001	<0.001	21.43	2.79–164.84	0.003
> 4	<0.001	15.73	1.86–132.81	0.011	<0.001	11.85	1.35–103.70	0.025
Type of melanoma	<0.001	1.58	0.95–2.62	0.078	<0.001	1.57	0.88–2.79	0.128
Ulceration	<0.001	1.83	1.09–3.07	0.023	<0.001	1.64	0.89–3.04	0.116
Lymphatic invasion	<0.001	3.98	2.05–7.72	<0.001	<0.001	2.19	1.07–4.48	0.032
Sentinel node status	<0.001	3.87	2.23–6.70	<0.001	<0.001	3.19	1.75–5.81	<0.001