Table 4.

Comparisons of time spent within, under and above the therapeutic range by users of co-trimoxazole and other antibiotics^a

	Mean difference	P	Adjusted mean differenceb	P
PDR applied
Co-trimoxazole, % time within TRc	−5.1 (−17.2 to 6.9)	0.40	−4.2 (−17.1 to 8.6)	0.51
Co-trimoxazole, % time above TR	2.7 (−7.3 to 12.7)	0.60	1.9 (−8.9 to 12.7)	0.73
Co-trimoxazole, % time under TR	2.4 (−6.3 to 11.1)	0.58	N.A.d
Other antibiotics	Reference		Reference
PDR not applied
Co-trimoxazole, % time within TR	−23.8 (−38.2 to –9.6)	< 0.001*	−22.3 (−36.6 to –8.0)e	0.002*
Co-trimoxazole, % time above TR	1.4 (−11.7 to 14.5)	0.83	N.A.
Co-trimoxazole, % time under TR	22.5 (14.4 to 30.6)	< 0.001*	20.4 (12.4 to 28.5)f	< 0.001*
Other antibiotics	Reference		Reference
Co-trimoxazole
PDR applied, % time within TR	19.3 (0.7 to 37.9)	0.042*	14.6 (−5.8 to 35.1)f	0.16
PDR applied, % time above TR	−5.3 (−19.6 to 9.0)	0.46	−4.4 (−19.1 to 10.3)g	0.55
PDR applied, % time under TR	−14.0 (−31.6 to 3.6)	0.16	−10.7 (−29.0 to 7.5)g	0.24
PDR not applied	Reference		Reference
Other antibiotics
PDR applied, % time within TR	0.5 (−7.0 to 8.1)	0.89	0.6 (−6.8 to 8.2)	0.87
PDR applied, % time above TR	−6.6 (−13.5 to 0.3)	0.061	N.A.
PDR applied, % time under TR	6.1 (2.0 to 10.1)	0.003*	N.A.
PDR not applied	Reference		Reference
Co-trimoxazole, PDR applied
% time within TR	−4.7 (−15.1 to 5.6)	0.37	−3.0 (−13.5 to 7.5)f	0.58
% time above TR	−2.4 (−11.9 to 7.1)	0.61	−3.7 (−13.3 to 6.0)h	0.46
% time under TR	7.2 (1.2 to 13.1)	0.018*	6.9 (1.0 to 12.9)h	0.022*
Other antibiotics
PDR applied + PDR not applied	Reference		Reference

*Statistically significant difference at P ≤ 0.05

^aCalculated for the time from the starting date of the antibiotic until the last INR measurement within 6 weeks following the starting date of the antibiotic.

^bAdjusted for differences in fever as indicated by patient, age, sex, target therapeutic range, unless otherwise indicated.

^cTR, Therapeutic range;

^dN.A., Adjustment not applied because including covariates in our model did not result in a change of at least 5 % of mean difference (see text).

^eAdjusted for differences in sex.

^fAdjusted for differences in sex and target therapeutic range.

^gAdjusted for differences in age, sex and target therapeutic range.

^hAdjusted for differences in sex, target therapeutic range and fever as indicated by patients.