Table 2.
Rate ratios of endometrial cancer according to baseline alcohol consumption in the Netherlands Cohort Study, 1986–1997
| Alcohol consumption (g/ day) | Age adjusted | Multivariate adjusted | |||||
|---|---|---|---|---|---|---|---|
| Categorical median | Cases | Person-years in subcohort | RR (95% CI)a | Cases | Person-years in subcohort | RR (95% CI)b | |
| Total alcohol | |||||||
| No | 0 | 91 | 6,641 | 1 (ref.) | 82 | 5,837 | 1 (ref.) |
| Yes | 4.0 | 189 | 13,746 | 1.01 (0.77–1.32) | 172 | 12,137 | 1.06 (0.78–1.43) |
| 0.1–4 | 1.6 | 114 | 7,599 | 1.10 (0.82–1.48) | 105 | 6,643 | 1.09 (0.78–1.52) |
| 5–14 | 9.1 | 47 | 3,640 | 0.94 (0.65–1.37) | 39 | 3,279 | 0.95 (0.62–1.45) |
| 15–29 | 20.9 | 17 | 1,822 | 0.69 (0.40–1.18) | 17 | 1,575 | 0.94 (0.52–1.69) |
| ≥30 | 37.3 | 11 | 684 | 1.20 (0.62–2.34) | 11 | 639 | 1.78 (0.88–3.60) |
| p trend | 0.49 | 0.62 | |||||
| Alcohol from wine | |||||||
| Yes | 3.2 | 182 | 13,009 | 1.06 (0.81–1.37) | 166 | 11,507 | 1.13 (0.84–1.52) |
| 0.1–4 | 1.5 | 125 | 8,072 | 1.17 (0.88–1.55) | 112 | 7,113 | 1.16 (0.84–1.59) |
| 5–14 | 8.9 | 38 | 3,146 | 0.91 (0.61–1.36) | 35 | 2,784 | 1.07 (0.68–1.67) |
| ≥15 | 21.8 | 19 | 1,791 | 0.80 (0.48–1.35) | 19 | 1,611 | 1.11 (0.64–1.93) |
| p trend | 0.43 | 0.64 | |||||
| Alcohol from beer | |||||||
| Yes | 1.14 | 29 | 1,873 | 1.15 (0.76–1.74) | 26 | 1,629 | 1.30 (0.82–2.07) |
| Alcohol from liquor | |||||||
| Yes | 3.7 | 34 | 2,648 | 0.93 (0.64–1.37) | 31 | 2,349 | 1.11 (0.73–1.68) |
aRR = rate ratios; CI = confidence interval; n.a. = not applicable
bRate ratios adjusted for age (years), body mass index (kg/m2), parity (number of children), use of oral contraceptives (ever versus never), non-occupational physical activity (low, moderate, active, very active), hypertension (yes versus no), age at first child birth (years), age at menopause (years), and current cigarette smoking (yes versus no)