Figure 4. Deterministic Model of the Dynamics of Resistant Viruses under the One-Drug, One-Mutant, One-Cell Version of Our Target-Cell Model.

(A) Slow turnover rates for CD4⁺ target cells (m = 0.02, k = 0.0005).

(B) Rapid turnover rates for CD4⁺ target cells (m = 0.32, k = 0.008).

Here m and k were increased proportionately so as to isolate the effect of changing turnover rate without altering pre-therapy viral load. Blue lines, WT virus; red lines, drug-resistant virus; green lines, target cells. These simulations assume a high cost of resistance (w ₁ = k ₁/k = 0.6). Other parameters are as in Table 2 assuming a single population of short-lived infected cells. Interpretation: these simulations illustrate previous theoretical studies showing the concentration of drug-resistant viruses declines transiently following the initiation of therapy.