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. 2007 Jul 13;3(7):e133. doi: 10.1371/journal.pcbi.0030133

Figure 8. Simulations Demonstrating the Effects of Cross-Resistance on Treatment Success Rates.

Figure 8

As in Figures 5–7, (A) demonstrates success rates as the duration of induction therapy is increased, and (B) demonstrates success rates over a range of induction therapy/therapy intensification start times. The different lines quantify the degree of resistance that mutations 3 and 4 confer against drugs III and II, respectively. x-Axis indicates duration of induction therapy in days (A), or interval between start of a 30-d induction therapy and maintenance therapy, in days (B). Maintenance therapy is assumed to start on day 0. y-Axis indicates percentage of simulations in which viral load remained undetectable for at least 3 y after ending induction therapy. Data in each panel were based on 400 simulations. Interpretation: IM therapy success rates decrease with the degree of cross-resistance between mutations 3 and 4.