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American Journal of Human Genetics logoLink to American Journal of Human Genetics
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. 1996 Apr;58(4):885–888.

The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11.

K Komatsu, S Matsuura, H Tauchi, S Endo, S Kodama, D Smeets, C Weemaes, M Oshimura
PMCID: PMC1914668  PMID: 8644753

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gatti R. A., Berkel I., Boder E., Braedt G., Charmley P., Concannon P., Ersoy F., Foroud T., Jaspers N. G., Lange K. Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. Nature. 1988 Dec 8;336(6199):577–580. doi: 10.1038/336577a0. [DOI] [PubMed] [Google Scholar]
  2. Jaspers N. G., Taalman R. D., Baan C. Patients with an inherited syndrome characterized by immunodeficiency, microcephaly, and chromosomal instability: genetic relationship to ataxia telangiectasia. Am J Hum Genet. 1988 Jan;42(1):66–73. [PMC free article] [PubMed] [Google Scholar]
  3. Jongmans W., Verhaegh G. W., Jaspers N. G., Oshimura M., Stanbridge E. J., Lohman P. H., Zdzienicka M. Z. Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer. Am J Hum Genet. 1995 Feb;56(2):438–443. [PMC free article] [PubMed] [Google Scholar]
  4. Komatsu K., Kodama S., Okumura Y., Koi M., Oshimura M. Restoration of radiation resistance in ataxia telangiectasia cells by the introduction of normal human chromosome 11. Mutat Res. 1990 Mar;235(2):59–63. doi: 10.1016/0921-8777(90)90058-d. [DOI] [PubMed] [Google Scholar]
  5. Komatsu K., Okumura Y., Kodama S., Yoshida M., Miller R. C. Lack of correlation between radiosensitivity and inhibition of DNA synthesis in hybrids (A-T x HeLa). Int J Radiat Biol. 1989 Dec;56(6):863–867. doi: 10.1080/09553008914552331. [DOI] [PubMed] [Google Scholar]
  6. McConville C. M., Byrd P. J., Ambrose H. J., Taylor A. M. Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23. Int J Radiat Biol. 1994 Dec;66(6 Suppl):S45–S56. [PubMed] [Google Scholar]
  7. Murnane J. P., Painter R. B. Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells. Proc Natl Acad Sci U S A. 1982 Mar;79(6):1960–1963. doi: 10.1073/pnas.79.6.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Savitsky K., Bar-Shira A., Gilad S., Rotman G., Ziv Y., Vanagaite L., Tagle D. A., Smith S., Uziel T., Sfez S. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science. 1995 Jun 23;268(5218):1749–1753. doi: 10.1126/science.7792600. [DOI] [PubMed] [Google Scholar]
  9. Shiloh Y. Ataxia-telangiectasia: closer to unraveling the mystery. Eur J Hum Genet. 1995;3(2):116–138. doi: 10.1159/000472285. [DOI] [PubMed] [Google Scholar]
  10. Stumm M., Gatti R. A., Reis A., Udar N., Chrzanowska K., Seemanova E., Sperling K., Wegner R. D. The ataxia-telangiectasia-variant genes 1 and 2 are distinct from the ataxia-telangiectasia gene on chromosome 11q23.1. Am J Hum Genet. 1995 Oct;57(4):960–962. [PMC free article] [PubMed] [Google Scholar]
  11. Verhaegh G. W., Jaspers N. G., Lohman P. H., Zdzienicka M. Z. Co-dominance of radioresistant DNA synthesis in a group of AT-like Chinese hamster cell mutants. Cytogenet Cell Genet. 1993;63(3):176–180. doi: 10.1159/000133528. [DOI] [PubMed] [Google Scholar]
  12. Verhaegh G. W., Jongmans W., Jaspers N. G., Natarajan A. T., Oshimura M., Lohman P. H., Zdzienicka M. Z. A gene that regulates DNA replication in response to DNA damage is located on human chromosome 4q. Am J Hum Genet. 1995 Nov;57(5):1095–1103. [PMC free article] [PubMed] [Google Scholar]
  13. Weemaes C. M., Hustinx T. W., Scheres J. M., van Munster P. J., Bakkeren J. A., Taalman R. D. A new chromosomal instability disorder: the Nijmegen breakage syndrome. Acta Paediatr Scand. 1981 Jul;70(4):557–564. doi: 10.1111/j.1651-2227.1981.tb05740.x. [DOI] [PubMed] [Google Scholar]
  14. Wegner R. D., Metzger M., Hanefeld F., Jaspers N. G., Baan C., Magdorf K., Kunze J., Sperling K. A new chromosomal instability disorder confirmed by complementation studies. Clin Genet. 1988 Jan;33(1):20–32. [PubMed] [Google Scholar]
  15. Zdzienicka M. Z., Verhaegh G. W., Jongmans W., Morolli B., Jaspers N. G., Oshimura M. Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells. Int J Radiat Biol. 1994 Dec;66(6 Suppl):S189–S195. [PubMed] [Google Scholar]

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